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Extra heartbeat and coffee1/17/2024 Regarding the finding that coffee consumption was related to increased PVC counts, she said that among healthy individuals with no CVD we should not get too worried about the PVCs.Researchers outfitted 100 healthy volunteers with gadgets that continuously monitored their heart function, daily steps, sleep patterns and blood sugar. She was glad to see that coffee consumption appears to increase physical activity and hopes that this translates to better CV health. Elaine Hylek, MD (Boston, MA, USA) who admitted to be a coffee drinker, felt somewhat reassured by this small study that showed that coffee consumption does not appear to induce atrial arrhythmias. Gregory M Marcus, MD said that these results suggest that individuals prone to PVCs or ventricular arrhythmias may benefit from coffee abstinence, but genetic differences influence risk. Coffeee consumption was not related to atrial arrhythmias. This study gave daily random assignments to a hundred volunteers to either drink as much coffee as they liked or to avoid all caffeinated products and found that coffee consumption resulted in more daily PVC counts, more physical activity as assessed by steps per day and less sleep duration. There was no significant relationship between random assignment to coffee consumption or per-protocol coffee consumption and daily mean glucose levels. Individuals with slow caffeine metabolism experienced a more potent effect of coffee on sleep. Random assignment to drink coffee was associated with 1,058 more steps per day (95% CI 441-1675, P=0.0010) and 36 less minutes sleep per night (95%CI 22-50, PIn per-protocol analyses, coffee consumption (per real-time coffee drink) was related to less SVT episodes.There was no significant relationship between random assignment to coffee consumption PAC counts, SVT episodes and VT episodes.Individuals with fast caffeine metabolism were at higher relative risk of PVCs. Random assignment to coffee consumption was associated with more PVCs (RR 1.54, 95%CI 1.19-2.00, P=0.001).Secondary outcomes included daily supraventricular tachycardia (SVT) and ventricular tachycardia (VT) counts, daily mean step counts, nightly mean sleep duration and daily mean glucose levels. Primary outcomes were daily premature atrial contraction (PAC) and premature ventricular contraction (PVC) counts. Costs for coffee purchases were reimbursed during the study. In addition, geolocation data was collected to geofence visits to coffee shops. They were instructed to press a button on the ECG patch to time-stamp every coffee drink and filled in daily surveys about the actual coffee consumption on the previous day. In addition, participants provided a saliva sample which was used to genotype DNA for caffeine metabolism-related SNPs. Participants were fitted with a wrist-worn Fitbit device which tracked physical activity and sleep, a wearable continuous ECG device and a continuous glucose monitor. The participants received texts and reminders with the daily random assignments. This randomized trial aimed to assess the real-time effects of coffee consumption on cardiac ectopy, physical activity, sleep and glucose levels.Ī hundred adult volunteers (mean age 38☑3 years, 51% women) who consumed coffee were randomized on a daily basis for 14 days to either consume as much coffee as they liked or avoid coffee and all caffeinated products. Gregory M Marcus, MD - San Francisco, CA, USA. Presented at the American Heart Association’s Scientific Sessions 2021 by: Prof. The Coffee And Real-time Atrial And Ventricular Ectopy (CRAVE) Trial
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